Bumetanide

July 24th, 2021 | drugs

Generic name: bumetanide (bue-MET-a-nide) (Oral route)
Drug class: Loop diuretics

Oral route(Tablet)

Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient's needs .

Uses for Bumex

Bumetanide belongs to a group of medicines called loop diuretics or "water pills." Bumetanide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine .

This medicine is available only with your doctor's prescription .

Before using Bumex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of bumetanide in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of bumetanide in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment of dosage in patients receiving bumetanide .

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Desmopressin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac
Acemetacin
Amtolmetin Guacil
Arsenic Trioxide
Aspirin
Bepridil
Bromfenac
Bufexamac
Celecoxib
Choline Salicylate
Clonixin
Dexibuprofen
Dexketoprofen
Diclofenac
Diflunisal
Digitoxin
Dipyrone
Dofetilide
Droperidol
Droxicam
Etodolac
Etofenamate
Etoricoxib
Felbinac
Fenoprofen
Fepradinol
Feprazone
Floctafenine
Flufenamic Acid
Flurbiprofen
Foscarnet
Ibuprofen
Indomethacin
Ketanserin
Ketoprofen
Ketorolac
Levomethadyl
Lithium
Lornoxicam
Loxoprofen
Lumiracoxib
Meclofenamate
Mefenamic Acid
Meloxicam
Metolazone
Morniflumate
Nabumetone
Naproxen
Nepafenac
Niflumic Acid
Nimesulide
Nimesulide Beta Cyclodextrin
Oxaprozin
Oxyphenbutazone
Parecoxib
Phenylbutazone
Piketoprofen
Piroxicam
Proglumetacin
Propyphenazone
Proquazone
Rofecoxib
Salicylic Acid
Salsalate
Sodium Salicylate
Sotalol
Sulindac
Tenoxicam
Tiaprofenic Acid
Tolfenamic Acid
Tolmetin
Valdecoxib

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Alacepril
Benazepril
Captopril
Cilazapril
Delapril
Dibekacin
Enalapril
Enalaprilat
Fosinopril
Germanium
Ginseng
Gossypol
Imidapril
Kanamycin
Licorice
Lisinopril
Moexipril
Neomycin
Pentopril
Perindopril
Quinapril
Ramipril
Spirapril
Streptomycin
Temocapril
Trandolapril
Zofenopril

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper use of Bumex

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):
- For edema:
  - Adults—0.5 to 2 milligrams (mg) once a day. Your doctor may adjust your dose if needed.
  - Children—Use and dose must be determined by your doctor .

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using Bumex

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects .

This medicine may cause you to lose more potassium from your body than normal. Your doctor will monitor the potassium in your blood while you are taking this medicine. To prevent the loss of too much water and potassium, tell your doctor if you become sick with severe or continuing nausea, vomiting, or diarrhea. Check with your doctor right away if you have one or more of these symptoms: dry mouth; increased thirst; muscle cramps; or nausea or vomiting .

Bumetanide can lower the number of platelets in your blood. Platelets are necessary for proper blood clotting. Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin .

This medicine may cause changes in your blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor .

Bumex side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal pain
blurred vision
confusion
decreased urine output
dizziness
drowsiness
dry mouth
fast or irregular heartbeat
flushed, dry skin
fruit-like breath odor
headache
increased hunger
increased thirst
increased urination
irritability
joint pain, stiffness, or swelling
loss of appetite
loss of mental alertness
lower back, side, or stomach pain
mood or mental changes
muscle pain or cramps
nausea or vomiting
numbness or tingling in the hands, feet, or lips
shortness of breath
sweating
swelling of face, hands, feet, ankles, or lower legs
troubled breathing
unexplained weight loss
unusual tiredness or weakness
weak pulse

Rare

Agitation
back pain
black, tarry stools
bleeding gums
blood in the urine or stools
chest pain
convulsions (seizures)
deep or fast breathing with dizziness
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
fever
hallucinations
hives
increase in heart rate
increased blood pressure
numbness of feet, hands, and around the mouth
pinpoint red spots on the skin
rapid breathing
stiff neck
sunken eyes
trembling, jerking of hands
unusual bleeding or bruising
weight gain
wrinkled skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Difficulty breathing
pain in chest, groin, or legs, especially the calves
severe, sudden headache
slurred speech
sudden loss of coordination
sudden, severe weakness or numbness in the arm or leg
sudden, unexplained shortness of breath
unusual drowsiness, dullness, or feeling of sluggishness
vision changes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: